LYMPHOID NEOPLASIA Trisomy 12 and elevated GLI1 and PTCH1 transcript levels are biomarkers for Hedgehog-inhibitor responsiveness in CLL
نویسندگان
چکیده
1Department of Hematology/Oncology, University Medical Center Freiburg, Freiburg, Germany; 2Faculty of Biology, University of Freiburg, Freiburg, Germany; 3Clinical Trials Unit, Department of Medical Biometry and Statistics and 4Department of Pathology, University Medical Center Freiburg, Freiburg, Germany; 5H3 Biomedicine, Cambridge, MA; and 6Department of Hematology, Leiden University Medical Center, Leiden, The Netherlands
منابع مشابه
Trisomy 12 and elevated GLI1 and PTCH1 transcript levels are biomarkers for Hedgehog-inhibitor responsiveness in CLL.
Hedgehog (HH) signaling is activated in various lymphoid malignancies, but conflicting results exist about its role in chronic lymphocytic leukemia (CLL). Here, we demonstrate that the expression of essential HH pathway components like GLI1, PTCH1, and the HH ligands is highly diverse in CLL. A subset of 36.7% of 60 tested CLL samples responded to all 3 SMOOTHENED (SMO) inhibitors, whereas 40% ...
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